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Tuesday, July 28, 2009

Long-term Outcomes and Clinical Predictors for Pacing After Cardiac Transplantation

Background
Prior studies have yielded inconsistent results on bradyarrhythmias requiring a permanent pacemaker (PPM) after cardiac transplant. This study evaluated the predictors for PPM requirement, long-term outcomes, and influence of implant timing and device programming on prognosis after cardiac transplant.

Methods
This study prospectively evaluated 1,307 recipients from 1985 to 2007 at Cleveland Clinic by structured follow-up and compared the outcomes of patients with and without bradyarrhythmias requiring PPM after transplantation. The primary end point was all-cause mortality or retransplant.

Results
Recipients, aged 50 ± 15 years (donors, 33 ± 14 years), were monitored 82 ± 59 months, with PPM indicated in 106 (8.1%), including 61 (57.5%) early and 44 (42.5%) late. Biatrial technique strongly predicted PPM requirement (OR [odds ratio], 2.61; 95% confidence interval [CI], 1.63–4.20; p < p =" 0.480)" p =" 0.550)" p =" 0.960)." p =" 0.02)">

Conclusions
No excess mortality is associated with a PPM after cardiac transplantation, and biatrial technique strongly predicts PPM requirement. Increased atrial fibrillation among PPM recipients may be related to right ventricular stimulation with dual-chamber pacing.


The Journal of Heart and Lung Transplantation, 07/28/09

2 comments:

  1. The surgery equipment are used in various features such as creating cuts during function while others are used for positioning like the forceps and others used in sewing the cuts.
    Surgical Instruments

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  2. Surgery is the division of medicine that surgically replaces an organ that is no longer functioning with an organ from a donor that does function. Organs are donated by living and deceased donors in order to save the life of a recipient. Dental Instruments

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